Where not to use Node.js?

The below are some listed points over where we are not using Node.js?

a)      Nested callback hell.

b)     In Node.js, any CPU intensive computation will block the responsiveness.

c)      Dealing with files can be a bit of a pain.

d)     In Node.js, the relational database is a bit of a pain.

e)      It's asynchronous programming model not for synchronous model.